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##  11 results 

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### 2023

Sarah Nichols, Emil Nilsson, Heather Brown-Harding, Leslie EW LaConte, Julia Acker, Alexander Borodavka, and Sarah McDonald Esstman. 2023. “[Flexibility of the Rotavirus NSP2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation](/publications/flexibility-rotavirus-nsp2-c-terminal-region-supports-factory-formation)”. Journal of Virology, Pp. e00039-23



 

 

Sarah Nichols, Emil Nilsson, Heather Brown-Harding, Leslie EW LaConte, Julia Acker, Alexander Borodavka, and Sarah McDonald Esstman. 2023. “[Flexibility of the Rotavirus NSP2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation](/publications/flexibility-rotavirus-nsp2-c-terminal-region-supports-factory-formation)”. Journal of Virology, Pp. e00039-23



 

 

 

 

 



### 2022

Qiwei Hu, Rama Yammani, Heather Brown-Harding, David Soto-Pantoja, Leslie Poole, and John Lukesh. 2022. “[Mitigation of Doxorubicin-Induced Cardiotoxicity With an HO-Activated, HS-Donating Hybrid Prodrug](/publications/mitigation-doxorubicin-induced-cardiotoxicity-ho-activated-hs-donating)”. Redox Biol, 53, Pp. 102338. doi:10.1016/j.redox.2022.102338



 

 

Qiwei Hu, Rama Yammani, Heather Brown-Harding, David Soto-Pantoja, Leslie Poole, and John Lukesh. 2022. “[Mitigation of Doxorubicin-Induced Cardiotoxicity With an HO-Activated, HS-Donating Hybrid Prodrug](/publications/mitigation-doxorubicin-induced-cardiotoxicity-ho-activated-hs-donating)”. Redox Biol, 53, Pp. 102338. doi:10.1016/j.redox.2022.102338



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Doxorubicin (DOX) is one of the most effective anticancer agents in clinical oncology. Its continued use, however, is severely limited by its dose-dependent cardiotoxicity which stems, in part, from its overproduction of reactive oxygen species (ROS) and... 

 

 

 

 



### 2020

Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique Biavatti, Kimberly Nelson, Leslie Poole, William Lowther, Paul Jones, Cristina Furdui, and Allen Tsang. 2020. “[Discovery of Spilanthol Endoperoxide As a Redox Natural Compound Active Against Mammalian Prx3 and Infection](/publications/discovery-spilanthol-endoperoxide-redox-natural-compound-active-against)”. Antioxidants (Basel), 9, 12. doi:10.3390/antiox9121220



 

 

Rosine Dushime, Yunhuang Zhu, Hanzhi Wu, Daniel Saez, Kirtikar Shukla, Heather Brown-Harding, Maique Biavatti, Kimberly Nelson, Leslie Poole, William Lowther, Paul Jones, Cristina Furdui, and Allen Tsang. 2020. “[Discovery of Spilanthol Endoperoxide As a Redox Natural Compound Active Against Mammalian Prx3 and Infection](/publications/discovery-spilanthol-endoperoxide-redox-natural-compound-active-against)”. Antioxidants (Basel), 9, 12. doi:10.3390/antiox9121220



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 *Chlamydia trachomatis* (Ct) is a bacterial intracellular pathogen responsible for a plethora of diseases ranging from blindness to pelvic inflammatory diseases and cervical cancer. Although this disease is effectively treated with antibiotics, concerns for... 

 

 

 

Xiyuan Yao, Noah Watkins, Heather Brown-Harding, and Ulrich Bierbach. 2020. “[A Membrane Transporter Determines the Spectrum of Activity of a Potent Platinum-Acridine Hybrid Anticancer Agent](/publications/membrane-transporter-determines-spectrum-activity-potent-platinum)”. Sci Rep, 10, 1, Pp. 15201. doi:10.1038/s41598-020-72099-z



 

 

Xiyuan Yao, Noah Watkins, Heather Brown-Harding, and Ulrich Bierbach. 2020. “[A Membrane Transporter Determines the Spectrum of Activity of a Potent Platinum-Acridine Hybrid Anticancer Agent](/publications/membrane-transporter-determines-spectrum-activity-potent-platinum)”. Sci Rep, 10, 1, Pp. 15201. doi:10.1038/s41598-020-72099-z



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum... 

 

 

 

Christelle Bouchard, Jay Michaels, and Heather Brown-Harding. 2020. “[RNA Isolation from Corals and Other Cnidarian Species Using Urea-LiCl As a Denaturant](/publications/rna-isolation-corals-and-other-cnidarian-species-using-urea-licl)”. Anal Biochem, 588, Pp. 113472. doi:10.1016/j.ab.2019.113472



 

 

Christelle Bouchard, Jay Michaels, and Heather Brown-Harding. 2020. “[RNA Isolation from Corals and Other Cnidarian Species Using Urea-LiCl As a Denaturant](/publications/rna-isolation-corals-and-other-cnidarian-species-using-urea-licl)”. Anal Biochem, 588, Pp. 113472. doi:10.1016/j.ab.2019.113472



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 A method of RNA isolation using a solution of urea-LiCl as a denaturing agent was tested on stony coral. As the method does not require homogenization of tissues prior to their incubation in the denaturant, specimen collected in the field can be... 

 

 

 

Israel Suarez, Caroline Warner, Heather Brown-Harding, Andrea Thooft, Brett VanVeller, and John Lukesh. 2020. “[Highly Selective Staining and Quantification of Intracellular Lipid Droplets With a Compact Push-Pull Fluorophore Based on Benzothiadiazole](/publications/highly-selective-staining-and-quantification-intracellular-lipid-droplets)”. Org Biomol Chem, 18, 3, Pp. 495-99. doi:10.1039/c9ob02486g



 

 

Israel Suarez, Caroline Warner, Heather Brown-Harding, Andrea Thooft, Brett VanVeller, and John Lukesh. 2020. “[Highly Selective Staining and Quantification of Intracellular Lipid Droplets With a Compact Push-Pull Fluorophore Based on Benzothiadiazole](/publications/highly-selective-staining-and-quantification-intracellular-lipid-droplets)”. Org Biomol Chem, 18, 3, Pp. 495-99. doi:10.1039/c9ob02486g



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 A robust lipophilic dye, based on the structures of the benzothiadiazole heterocycle, was shown to be a potent fluorescent stain for the selective imaging of lipid droplets (LDs) within both live and fixed human cells. Its small molecular framework, large... 

 

 

 

 



### 2019

Daniel Saez, Rosine Dushime, Hanzhi Wu, Lourdes Ramos Cordova, Kirtikar Shukla, Heather Brown-Harding, Cristina Furdui, and Allen Tsang. 2019. “[Sulforaphane Promotes Chlamydial Infection by Suppressing Mitochondrial Protein Oxidation and Activation of Complement C3](/publications/sulforaphane-promotes-chlamydial-infection-suppressing-mitochondrial)”. Protein Sci, 28, 1, Pp. 216-27. doi:10.1002/pro.3536



 

 

Daniel Saez, Rosine Dushime, Hanzhi Wu, Lourdes Ramos Cordova, Kirtikar Shukla, Heather Brown-Harding, Cristina Furdui, and Allen Tsang. 2019. “[Sulforaphane Promotes Chlamydial Infection by Suppressing Mitochondrial Protein Oxidation and Activation of Complement C3](/publications/sulforaphane-promotes-chlamydial-infection-suppressing-mitochondrial)”. Protein Sci, 28, 1, Pp. 216-27. doi:10.1002/pro.3536



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Sulforaphane (SFN), a phytochemical found in broccoli and other cruciferous vegetables, is a potent antioxidant and anti-inflammatory agent with reported effects in cancer chemoprevention and suppression of infection with intracellular pathogens. Here we... 

 

 

 

 



### 2018

Gloria Muday and Heather Brown-Harding. 2018. “[Nervous System-Like Signaling in Plant Defense](/publications/nervous-system-signaling-plant-defense)”. Science, 361, 6407, Pp. 1068-69. doi:10.1126/science.aau9813



 

 

Gloria Muday and Heather Brown-Harding. 2018. “[Nervous System-Like Signaling in Plant Defense](/publications/nervous-system-signaling-plant-defense)”. Science, 361, 6407, Pp. 1068-69. doi:10.1126/science.aau9813



 

 

 

 

 



### 2014

Heather Brown, Andrea Knowlton, Emily Snavely, Bidong Nguyen, Theresa Richards, and Scott Grieshaber. 2014. “[Multinucleation During C. Trachomatis Infections Is Caused by the Contribution of Two Effector Pathways](/publications/multinucleation-during-c-trachomatis-infections-caused-contribution-two)”. PLoS One, 9, 6, Pp. e100763. doi:10.1371/journal.pone.0100763



 

 

Heather Brown, Andrea Knowlton, Emily Snavely, Bidong Nguyen, Theresa Richards, and Scott Grieshaber. 2014. “[Multinucleation During C. Trachomatis Infections Is Caused by the Contribution of Two Effector Pathways](/publications/multinucleation-during-c-trachomatis-infections-caused-contribution-two)”. PLoS One, 9, 6, Pp. e100763. doi:10.1371/journal.pone.0100763



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Chlamydia trachomatis is an obligate intracellular bacterial pathogen and the second leading cause of sexually transmitted infections in the US. Infections cause significant morbidity and can lead to serious reproductive sequelae, including an... 

 

 

 

 



### 2012

Heather Brown, Andrea Knowlton, and Scott Grieshaber. 2012. “[Chlamydial Infection Induces Host Cytokinesis Failure at Abscission](/publications/chlamydial-infection-induces-host-cytokinesis-failure-abscission)”. Cell Microbiol, 14, 10, Pp. 1554-67. doi:10.1111/j.1462-5822.2012.01820.x



 

 

Heather Brown, Andrea Knowlton, and Scott Grieshaber. 2012. “[Chlamydial Infection Induces Host Cytokinesis Failure at Abscission](/publications/chlamydial-infection-induces-host-cytokinesis-failure-abscission)”. Cell Microbiol, 14, 10, Pp. 1554-67. doi:10.1111/j.1462-5822.2012.01820.x



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Chlamydia trachomatis is an obligate intracellular bacteria and the infectious agent responsible for the sexually transmitted disease Chlamydia. Infection with Chlamydia can lead to serious health sequelae such as pelvic inflammatory disease and... 

 

 

 

 



### 2011

Andrea Knowlton, Heather Brown, Theresa Richards, Lauren Andreolas, Rahul Patel, and Scott Grieshaber. 2011. “[Chlamydia Trachomatis Infection Causes Mitotic Spindle Pole Defects Independently from Its Effects on Centrosome Amplification](/publications/chlamydia-trachomatis-infection-causes-mitotic-spindle-pole-defects)”. Traffic, 12, 7, Pp. 854-66. doi:10.1111/j.1600-0854.2011.01204.x



 

 

Andrea Knowlton, Heather Brown, Theresa Richards, Lauren Andreolas, Rahul Patel, and Scott Grieshaber. 2011. “[Chlamydia Trachomatis Infection Causes Mitotic Spindle Pole Defects Independently from Its Effects on Centrosome Amplification](/publications/chlamydia-trachomatis-infection-causes-mitotic-spindle-pole-defects)”. Traffic, 12, 7, Pp. 854-66. doi:10.1111/j.1600-0854.2011.01204.x



 

 

 

- add\_circle do\_not\_disturb\_on Abstract
 
 Chlamydiae are Gram negative, obligate intracellular bacteria, and Chlamydia trachomatis is the etiologic agent of the most commonly reported sexually transmitted disease in the United States. Chlamydiae undergo a biphasic life cycle that takes place...